Dupixent Injection: Uses, Dosage, Side Effects, Warnings

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Dupixent Injection

Dupixent, also known as dupilumab, is a groundbreaking medication used to treat several chronic inflammatory conditions. It has shown remarkable efficacy in managing diseases like eczema, asthma, and chronic rhinosinusitis with nasal polyps.

Today, you will get to know everything about Dupixent, covering everything from what it is and how it works to its side effects and storage instructions.

What is Dupixent?

Dupixent is a biologic medication, meaning it is derived from living cells. It is specifically designed to target and inhibit the activity of certain proteins in the body that contribute to inflammation.

By blocking these proteins, Dupixent helps to reduce the symptoms of various inflammatory diseases. This medication is administered through injections and has been a game-changer for many patients whose conditions were previously difficult to manage.

Warnings

Before starting Dupixent, it’s crucial to be aware of certain warnings and precautions. This medication can potentially cause allergic reactions. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, and trouble breathing. If any of these symptoms occur, medical attention should be sought immediately.

Also, Dupixent may increase the risk of eye problems. Patients should notify their healthcare provider if they experience new or worsening eye symptoms, such as redness, itching, or vision changes. Regular eye exams may be recommended during treatment.

Before Taking Dupixent

Before starting Dupixent, discuss your medical history with your doctor, especially any history of:

  • Eye problems
  • Parasitic infections
  • Allergies to dupilumab or any of its ingredients

It is important to inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. This will help avoid potential drug interactions.

Pregnant or breastfeeding women should consult their doctor before using Dupixent. It is not known if Dupixent can harm an unborn baby or pass into breast milk.

How Should I Use Dupixent?

Dupixent is administered as an injection under the skin (subcutaneous injection). Here are the general steps for using Dupixent:

  • Wash your hands thoroughly. Remove the pre-filled syringe from the refrigerator and let it reach room temperature for about 45 minutes.
  • Check the syringe for any particles or discoloration. If the liquid looks cloudy, discolored, or contains particles, do not use it.
  • Choose an injection site on your thigh or abdomen, avoiding the area around the navel. Rotate injection sites with each dose.
  • Clean the injection site with an alcohol swab. Pinch the skin gently and insert the needle at a 45-degree angle. Press the plunger slowly and steadily until all the medicine is injected.
  • Dispose of the used syringe in a puncture-proof disposal container.

Always follow your healthcare provider’s instructions and the guidelines provided with the medication.

What Happens if I Miss a Dose?

If you miss a dose of Dupixent, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed dose.

What Happens if I Overdose?

In the event of an overdose, seek emergency medical attention or call the Poison Help line. Symptoms of overdose may include severe dizziness, fainting, and other unusual symptoms. Always follow the prescribed dosage to avoid any complications.

What Should I Avoid While Using Dupixent?

While using Dupixent, it is important to avoid certain activities and exposures that could interfere with the medication’s effectiveness or increase the risk of side effects. These include:

  • Avoid receiving live vaccines while using Dupixent. Live vaccines include measles, mumps, rubella, polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), and zoster (shingles).
  • Avoid exposure to infections and people who are sick, as Dupixent can lower your ability to fight infections.
  • Follow any specific dietary restrictions or lifestyle modifications recommended by your healthcare provider.

What Are the Side Effects of Dupixent?

Dupixent, like all medications, can cause side effects. It’s important to be aware of these potential side effects so you can recognize and address them promptly. Common side effects include:

  • Injection site reactions (redness, swelling, pain)
  • Eye problems (redness, itching, swelling)
  • Cold sores on the lips or in the mouth

More serious side effects are rare but can occur. These include:

  • Severe allergic reactions
  • Eye problems like conjunctivitis and keratitis
  • Eosinophilia (high levels of a type of white blood cell)

If you experience any severe side effects or symptoms of an allergic reaction, contact your healthcare provider immediately.

What Other Drugs Will Affect Dupixent?

Before starting Dupixent, it’s crucial to discuss all the medications you are taking with your healthcare provider. Dupixent can interact with other drugs, potentially affecting how they work or increasing the risk of side effects.

Inform your doctor about all prescription and over-the-counter medications, vitamins, and herbal supplements you are using. This will help prevent any adverse drug interactions.

Storage

Proper storage of Dupixent is essential to maintain its effectiveness. Follow these storage guidelines:

  • Store Dupixent in the refrigerator between 36°F and 46°F (2°C and 8°C).
  • Do not freeze Dupixent.
  • Keep the medication in its original carton to protect it from light.
  • If necessary, Dupixent can be stored at room temperature up to 77°F (25°C) for a maximum of 14 days. If not used within 14 days, discard the medication.
  • Keep Dupixent out of reach of children and pets.

Ingredients

Dupixent contains the active ingredient dupilumab, a monoclonal antibody. It also contains inactive ingredients such as L-arginine hydrochloride, L-histidine, polysorbate 80, sodium acetate, sucrose, and water for injection. If you have any known allergies to these ingredients, inform your healthcare provider.

Manufacturer

Dupixent is manufactured by Regeneron Pharmaceuticals, Inc., and Sanofi Genzyme. These companies have partnered to develop and distribute this medication, ensuring high standards of quality and efficacy.

People May Ask

How long does it take for Dupixent to work?

Many patients start to see improvement in their symptoms within 2 to 4 weeks of starting Dupixent. However, the full benefits may take several months to achieve.

Can I stop using Dupixent once my symptoms improve?

It is important to follow your healthcare provider’s instructions regarding the duration of treatment. Stopping Dupixent abruptly may cause your symptoms to return.

Is Dupixent a steroid?

A: No, Dupixent is not a steroid. It is a monoclonal antibody that targets specific proteins involved in inflammation.

Can Dupixent be used in children?

Yes, Dupixent is approved for use in children aged 6 years and older for certain conditions like eczema. Always consult a pediatrician before starting treatment.

Does Dupixent affect the immune system?

Dupixent can affect the immune system by reducing inflammation. While it helps manage symptoms, it may also increase the risk of infections. Regular monitoring by a healthcare provider is essential.

Conclusion

Dupixent has revolutionized the treatment of chronic inflammatory conditions like eczema, asthma, and chronic rhinosinusitis with nasal polyps. By targeting specific proteins in the body, it effectively reduces inflammation and improves symptoms, offering significant relief for many patients.

While it has potential side effects and requires careful administration, the benefits often outweigh the drawbacks. Always consult your healthcare provider to determine if Dupixent is the right treatment for you.