Entyvio (generic name: vedolizumab) is a monoclonal antibody used primarily to treat inflammatory bowel diseases (IBD) like ulcerative colitis and Crohn’s disease.
It works by targeting specific proteins that cause inflammation in the intestines, providing relief for patients suffering from chronic, debilitating digestive disorders.
In this article, we will cover everything you need to know about Entyvio, including its uses, dosage, side effects, and important precautions.
- Key Information About Entyvio
- What is Entyvio?
- How Does Entyvio Work?
- Medical Uses of Entyvio
- 1. Ulcerative Colitis
- 2. Crohn’s Disease
- How to Use Entyvio
- 1. Administration Method
- 2. Preparation for Treatment
- 3. Missed Dose
- Dosage Information for Entyvio
- Potential Side Effects of Entyvio
- Common Side Effects:
- Serious Side Effects:
- Warnings and Precautions
- 1. Infection Risk
- 2. Liver Problems
- 3. Progressive Multifocal Leukoencephalopathy (PML)
- Conclusion
- People May Ask
- 1. What is Entyvio used for?
- 2. How is Entyvio administered?
- 3. What are the side effects of Entyvio?
- 4. Can Entyvio cause infections?
- 5. How long does it take for Entyvio to work?
- Disclaimer
Key Information About Entyvio
| Feature | Details |
| Drug Class | Monoclonal Antibody, Immunosuppressant |
| Active Ingredient | Vedolizumab |
| Primary Uses | Ulcerative colitis, Crohn’s disease |
| Dosage Form | Intravenous (IV) infusion |
| Common Side Effects | Headache, joint pain, fever |
| Serious Side Effects | Serious infections, liver problems, allergic reactions |
| Pregnancy Category | Category C (Risk cannot be ruled out) |
| Breastfeeding | Consult a doctor before use |
What is Entyvio?
Entyvio is a biologic medication specifically designed to treat moderate to severe ulcerative colitis and Crohn’s disease, two forms of inflammatory bowel disease.
It works by targeting integrin receptors on white blood cells, preventing them from migrating into the gastrointestinal tract, where they cause inflammation. This mechanism reduces the immune system’s attack on the gut lining and helps control symptoms such as diarrhea, pain, and fatigue.
How Does Entyvio Work?
Entyvio is a humanized monoclonal antibody that specifically targets the α4β7 integrin, a protein found on the surface of white blood cells. This protein plays a key role in allowing these cells to enter the gastrointestinal tract and cause inflammation.
By blocking this protein, vedolizumab prevents white blood cells from accumulating in the gut, thereby reducing the inflammatory response and helping to control symptoms of Crohn’s disease and ulcerative colitis.
Unlike some other immunosuppressive treatments, Entyvio has a relatively targeted action, which means it is less likely to affect other parts of the immune system, reducing the risk of widespread immune suppression.
Medical Uses of Entyvio
1. Ulcerative Colitis
Entyvio is approved for the treatment of moderate to severe ulcerative colitis in adults. Ulcerative colitis is a chronic condition where the immune system attacks the colon, causing symptoms like bloody diarrhea, abdominal pain, and fatigue. Entyvio helps by reducing inflammation and promoting healing of the colon lining.
2. Crohn’s Disease
Entyvio is also used to treat moderate to severe Crohn’s disease, another type of inflammatory bowel disease that affects the small intestine and colon. This condition is characterized by intestinal inflammation, which can lead to pain, weight loss, and diarrhea. Entyvio helps control symptoms by suppressing the immune response in the intestines.
How to Use Entyvio
1. Administration Method
Entyvio is administered as an intravenous (IV) infusion. It is given in a clinical setting by a healthcare professional. The typical administration process is as follows:
- Initial Dosing: The first dose is usually given over 30 minutes, followed by subsequent doses at 2 weeks and 6 weeks.
- Maintenance Dosing: After the initial doses, Entyvio is typically given every 8 weeks.
2. Preparation for Treatment
- Pre-treatment screening: Before starting Entyvio, patients may need to undergo screening for infections such as tuberculosis (TB) and hepatitis B, as the medication can increase the risk of infections.
- Monitoring: During treatment, regular monitoring is essential, including blood tests and screening for signs of infection.
3. Missed Dose
If a dose is missed, it’s important to contact your healthcare provider for guidance on when to reschedule the infusion. Don’t attempt to make up for a missed dose without consulting a doctor.
Dosage Information for Entyvio
| Condition | Typical Dose | Frequency |
| Ulcerative Colitis | Initial dose: 300 mg IV | Every 2 weeks for the first 6 weeks, then every 8 weeks for maintenance |
| Crohn’s Disease | Initial dose: 300 mg IV | Every 2 weeks for the first 6 weeks, then every 8 weeks for maintenance |
Note: Dosing frequency may vary depending on the patient’s response to treatment.
Potential Side Effects of Entyvio
Common Side Effects:
- Headache
- Joint pain
- Fever
- Fatigue
- Nausea
Serious Side Effects:
- Serious infections, including tuberculosis, fungal infections, and bacterial infections.
- Liver problems, such as jaundice or elevated liver enzymes.
- Allergic reactions, which can cause rash, swelling, or difficulty breathing.
- Progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection that can occur in patients with weakened immune systems.
Warnings and Precautions
1. Infection Risk
Entyvio can suppress the immune system, which may increase the risk of serious infections. Prior to treatment, patients must be screened for tuberculosis (TB), hepatitis B, and other infections. Patients should also report any signs of infection such as fever, chills, or persistent cough while on treatment.
2. Liver Problems
Entyvio can cause liver issues, so it’s important to monitor liver function regularly. Symptoms like yellowing of the skin or eyes (jaundice) or dark urine should be reported immediately.
3. Progressive Multifocal Leukoencephalopathy (PML)
Though rare, PML is a life-threatening condition that can occur when the immune system is suppressed. Patients should be monitored for neurological symptoms such as vision problems, difficulty walking, or cognitive changes.
Conclusion
Entyvio is an effective treatment option for people with moderate to severe ulcerative colitis and Crohn’s disease, helping to control inflammation and improve quality of life.
While it offers significant benefits, it is important to be aware of the potential side effects and precautions, especially regarding infection risks and liver health.
Patients should be regularly monitored by healthcare professionals to ensure the treatment is working and to minimize potential risks.
People May Ask
1. What is Entyvio used for?
Entyvio is used to treat moderate to severe ulcerative colitis and Crohn’s disease, two forms of inflammatory bowel disease.
2. How is Entyvio administered?
Entyvio is given as an intravenous infusion by a healthcare provider. The typical dosing schedule involves an initial dose, followed by infusions at 2-week and 6-week intervals, and then every 8 weeks for maintenance.
3. What are the side effects of Entyvio?
Common side effects include headache, joint pain, and fatigue. Serious side effects can include infections, liver problems, and neurological issues like PML.
4. Can Entyvio cause infections?
Yes, Entyvio can increase the risk of serious infections. Patients should be screened for infections before starting the medication and monitored during treatment.
5. How long does it take for Entyvio to work?
Many patients may start to see improvements within 6 weeks, but it can take up to 3 months to achieve full therapeutic benefit.
Disclaimer
This article is for informational purposes only and should not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment options, and any questions related to your health.
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