Liraglutide, marketed as Victoza, is a medication primarily used for managing type 2 diabetes and cardiovascular risk.
In addition, it is available in another formulation, Saxenda, for weight loss.
This injectable medication mimics the GLP-1 hormone, which helps regulate blood sugar, reduce appetite, and protect against heart-related events. Below is a complete breakdown of its uses, side effects, and other essential details.
- Key Details
- What is Liraglutide (Victoza)?
- How Liraglutide Works
- Common Uses of Liraglutide
- Storage Guidelines for Liraglutide
- Dosage and Administration
- Injection tips:
- Side Effects of Liraglutide
- Common Side Effects:
- Serious Side Effects:
- Who Should Not Use Liraglutide?
- Precautions Before Using Liraglutide
- Drug Interactions
- Conclusion
- People May Ask
- How long does it take for liraglutide to start working?
- Can liraglutide be used for weight loss?
- What should I do if I miss a dose?
- Can liraglutide be used for type 1 diabetes?
- Is liraglutide safe to use long-term?
- Disclaimer
Key Details
| Feature | Details |
| Generic Name | Liraglutide |
| Brand Names | Victoza (for diabetes and heart protection), Saxenda (for weight loss) |
| Drug Class | GLP-1 receptor agonist, incretin mimetic |
| Formulation | Injectable solution (pre-filled pens) |
| Common Dosages | 0.6 mg, 1.2 mg, 1.8 mg per injection |
| Route of Administration | Subcutaneous (under the skin) |
| Storage Instructions | Refrigerate before opening (36°F to 46°F), room temperature after opening (59°F to 86°F) |
| Availability | Prescription only |
| Special Notes | Rotate injection sites, avoid freezing, and follow healthcare provider’s advice |
What is Liraglutide (Victoza)?
Liraglutide is a GLP-1 receptor agonist designed to help control blood sugar levels in people with type 2 diabetes.
It works by mimicking the effects of the natural GLP-1 hormone, which stimulates insulin release, slows gastric emptying, and reduces appetite.
Additionally, liraglutide can reduce the risk of heart-related issues such as stroke and heart attack in people with diabetes and existing cardiovascular disease.
For weight loss, liraglutide is marketed as Saxenda, with a higher dosage specifically for managing obesity.
MUST READ: Wellbutrin XL 150 mg for Depression: How to Take, Risks, and Benefits Explained
How Liraglutide Works
Liraglutide improves blood sugar levels and metabolic function through three main mechanisms:
- Boosts Insulin Production: It prompts the pancreas to release insulin after meals, lowering blood sugar levels.
- Reduces Glucagon Levels: By decreasing glucagon production, it prevents excess glucose from being released by the liver.
- Delays Gastric Emptying: Slowing food movement in the stomach helps control appetite and supports weight loss
Common Uses of Liraglutide
- Type 2 Diabetes: Liraglutide helps lower blood sugar levels by improving insulin function and reducing glucose production in the liver.
- Cardiovascular Protection: In patients with type 2 diabetes and a history of heart disease, liraglutide lowers the risk of heart attacks, strokes, and death.
- Weight Loss: Saxenda, a higher-dose version of liraglutide, is prescribed to support weight loss in overweight individuals, particularly when diet and exercise alone have been insufficient.
Storage Guidelines for Liraglutide
Proper storage of liraglutide is crucial to ensure its effectiveness:
| Storage Condition | Before Opening | After Opening |
| Temperature | Refrigerated (36°F to 46°F or 2°C to 8°C) | Room temperature (59°F to 86°F or 15°C to 30°C) for up to 30 days |
| Avoid | Freezing or exposure to sunlight | Keep away from heat, store with cap on |
| Special Notes | Do not store next to cooling element | Do not attach needle during storage |
Once opened, store the pen at room temperature or in the fridge, and do not freeze it. Always check the expiration date before use.
Dosage and Administration
Liraglutide comes in a pre-filled pen and is injected subcutaneously once a day. The medication is typically administered into the abdomen, thigh, or upper arm.
The typical starting dose is 0.6 mg daily, with the dose gradually increased based on the individual’s needs and tolerance, up to a maximum of 1.8 mg per day.
Injection tips:
- Always rotate injection sites to prevent irritation.
- Use a new needle with each injection.
- Keep the pen in a safe place, away from children.
Side Effects of Liraglutide
Common Side Effects:
- Digestive Issues: Nausea, vomiting, diarrhea, or constipation.
- Decreased Appetite: Can lead to weight loss.
- Indigestion: Uncomfortable feelings after meals.
- Injection Site Reactions: Redness, swelling, or itching at the injection site.
These side effects are usually mild and may decrease after continued use. However, if symptoms persist or worsen, contact your healthcare provider.
Serious Side Effects:
- Allergic Reactions: Difficulty breathing, swelling of the face, throat, lips, or tongue.
- Thyroid Cancer Risk: Liraglutide may increase the risk of thyroid tumors, including medullary thyroid carcinoma. Seek medical attention if you notice a lump in your neck, hoarseness, or difficulty swallowing.
- Pancreatitis: Severe abdominal pain, nausea, and vomiting could be signs of inflammation of the pancreas.
- Kidney Problems: Symptoms include reduced urination, swelling, or unusual tiredness.
- Gallbladder Issues: Pain in the upper stomach, fever, or yellowing of the skin or eyes (jaundice).
Who Should Not Use Liraglutide?
Liraglutide is not suitable for certain individuals, including:
- People with Type 1 Diabetes: Liraglutide is intended only for type 2 diabetes management.
- Those with a History of Thyroid Cancer: Especially medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
- Individuals with Pancreatitis: If you’ve had inflammation of the pancreas, you should avoid liraglutide.
- Pregnant and Breastfeeding Women: The effects of liraglutide on pregnancy and breastfeeding are not well understood, so consult your doctor before use.
Precautions Before Using Liraglutide
Before starting liraglutide, discuss your full medical history with your healthcare provider, especially if you have:
- Gastrointestinal Disorders: Such as gastroparesis (delayed stomach emptying).
- Pancreas Issues: Including a history of pancreatitis.
- Kidney or Liver Problems: Kidney and liver conditions may require dose adjustments or alternative treatments.
Always follow your doctor’s advice, and do not self-medicate or share your medication with others.
Drug Interactions
Liraglutide may interact with other medications. Notably:
- Insulin and Sulfonylureas: These drugs can increase the risk of low blood sugar (hypoglycemia) when combined with liraglutide.
- Oral Medications: Liraglutide may delay gastric emptying, potentially affecting the absorption of other oral drugs.
- Other GLP-1 Agonists: Using liraglutide with other GLP-1 drugs like Saxenda can be dangerous.
Always disclose all your medications, including over-the-counter and herbal supplements, to your healthcare provider to avoid potential interactions.
Conclusion
Liraglutide (Victoza) is an effective medication for managing type 2 diabetes, reducing cardiovascular risk, and supporting weight loss. It works by improving insulin secretion, lowering blood sugar, and controlling appetite.
Like all medications, it has potential side effects and should be used under a doctor’s guidance.
Be aware of the serious risks, including thyroid issues and pancreatitis, and discuss any concerns with your healthcare provider.
People May Ask
How long does it take for liraglutide to start working?
Liraglutide begins to work within a few hours of administration, but it may take several weeks to see full effects on blood sugar and appetite regulation.
Can liraglutide be used for weight loss?
Yes, Saxenda, a higher dose of liraglutide, is specifically approved for weight management in individuals with obesity or who are overweight and have weight-related health problems.
What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not take two doses at once.
Can liraglutide be used for type 1 diabetes?
No, liraglutide is not indicated for the treatment of type 1 diabetes.
Is liraglutide safe to use long-term?
Liraglutide is generally considered safe for long-term use when prescribed by a healthcare provider and monitored regularly. However, as with any medication, there are risks associated with prolonged use, such as potential thyroid or pancreatic issues. It’s important to have regular follow-up appointments with your healthcare provider to assess the ongoing benefits and risks of the medication.
Disclaimer
This article provides general information and should not be considered as medical advice. Always consult with your healthcare provider before starting or adjusting any medication. The safety and effectiveness of treatments may vary based on individual health conditions.
Click here to learn more.
